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RECRUITINGNA

PET-study on the Role of the Reward System in Weight Loss After Bariatric Surgery

NCT05359887•University Medical Center Groningen

Summary

Bariatric surgery (BS) is currently the most effective treatment in severe obesity. However, a considerable percentage of patients undergoing BS fail to lose sufficient weight or regain weight after initial weight loss during long-term follow-up, which may be attributed to personality traits and pathological eating behaviour. Previous positron emission tomography (PET) studies have shown reduced dopamine D2 receptor availability in obese patients and upregulation of this availability following successful BS in the brain's reward system. Dopamine D2 receptor availability in patients with unsuccessful BS has not been investigated to date.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Bariatric surgery 24-36 months prior to the study
•Adult (over 18y old)
•Mentally capable to understand the consequences of the procedure and make his or her own choice without coercion
•Able to undergo PET and MRI, according to the investigator's assessment
•Native speaking
•Able to participate in follow-up
•Written informed consent

Exclusion Criteria

•Presence of a DSM-IV axis 1 disorder
•The use of drugs that bind to dopamine D2/3 receptors, including various classes of antipsychotics and antidepressants
•History of stroke, brain tumor, Parkinson's Disease or dementia
•History of head trauma with loss of consciousness
•Alcohol or substance abuse in the last 6 months
•Alcohol consumption 24h prior to PET scanning
•Smoking or other forms of nicotine intake 12 hours prior to PET scanning
•Use of anorectic drugs in the last 6 months
•Current pregnancy
•Medication for Diabetes Mellitus
+3 more criteria

Locations (1)

MCL

Leeuwarden, Netherlands

Key Dates

Start Date

December 1, 2022

Primary Completion Date

December 31, 2024

Completion Date

December 31, 2024

Last Updated

May 14, 2024

Enrollment

ESTIMATED participants

Conditions

Obesity

Interventions

standardized liquid mixed meal Nutridrink®

OTHER

Contacts

D.L. Marinus Oterdoom, MD

CONTACT

+31503612837 d.l.m.oterdoom@umcg.nl

Andre P. van Beek, MD PhD

CONTACT

a.p.van.beek@umcg.nl

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 14, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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PET-study on the Role of the Reward System in Weight Loss After Bariatric Surgery

Inclusion Criteria

Exclusion Criteria

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