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Randomized, placebo-controlled trial of oral calcium supplementation for osteopenia in girls and women with Rett syndrome
Objective: The investigators conducted a randomized, double-blind, placebo-controlled trial to determine the safety and efficacy of oral calcium supplementation for the treatment of bone mineral deficits in individuals with Rett syndrome (RTT). Methods: The investigators measured total body bone mineral content (BMC) and bone mineral density (BMD) by dual-energy x-ray absorptiometry and biomarkers of bone turnover by clinical laboratory techniques before and one year after oral calcium or placebo supplementation in 32 pre- and post-pubertal girls and young women with RTT. The calcium supplement was calculated to provide a twofold increase in the recommended dietary allowance of calcium for age.
Age
5 - 30 years
Sex
FEMALE
Healthy Volunteers
No
Start Date
March 1, 2008
Primary Completion Date
March 1, 2012
Completion Date
March 1, 2012
Last Updated
April 28, 2022
32
ACTUAL participants
calcium
DIETARY_SUPPLEMENT
placebo
DIETARY_SUPPLEMENT
Lead Sponsor
Baylor College of Medicine
NCT06338267
NCT06856759
NCT04463316
Data Source & Attribution
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