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Sugars in Cigarettes | Clinical Trials | Clareo Health

COMPLETEDNA

Sugars in Cigarettes

Impact of Sugars on Tobacco Product Toxicity and Abuse Liability

NCT05308316•Masonic Cancer Center, University of Minnesota

Summary

The aim of this study is to investigate the impact of sugar levels in cigarette tobacco on cigarette abuse liability and appeal. Participants will attend several clinic visits to smoke cigarettes with different levels of sugars and will complete multiple questionnaires to assess their experiences. Each of the sessions will be separated by at least 48 hours but not more than 5 days. The hypothesis is that the measures collected in this study will indicate lower abuse liability for cigarettes with lowest sugar content.

Eligibility

Age

21 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Male or female age 21 years or older
•Smoking cigarettes that have been evaluated to have medium levels of sugar content
•No quit attempts in the past month nor intentions to quit smoking in the next month
•Participants are in good physical health (no unstable medical conditions) as determined by the licensed medical professional
•Participants are in stable, good mental health (e.g. not currently, within the past 6 months, experiencing unstable or untreated psychiatric diagnosis) as determined by the licensed medical professional
•Stable vitals sign measurements (systolic BP ≤ 160 and \>90 mmHg, diastolic BP ≤ 100 and \>50 mmHg and heart rate ≤105 and \> 45 bpm) as determined by the licensed medical professional
•Participants must be able to read for comprehension or completion of study documents (confirmed during informed consent process)
•Participants have provided written informed consent to participate in the study.

Exclusion Criteria

•Significant immune system disorders, respiratory diseases, kidney or liver diseases or any other medical disorders that may affect biomarker data as determined by the licensed medical professional
•Women who are pregnant or nursing or planning to become pregnant.

Locations (1)

Masonic Cancer Center at University of Minnesota

Minneapolis, Minnesota, United States

Key Dates

Start Date

February 24, 2022

Primary Completion Date

October 13, 2023

Completion Date

October 9, 2025

Last Updated

February 27, 2026

Enrollment

ACTUAL participants

Conditions

Tobacco Use

Interventions

Cigarettes with added sucrose

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 27, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Sugars in Cigarettes

Inclusion Criteria

Exclusion Criteria

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