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Lead
Charite University, Berlin, Germany
A remission of type 2 diabetes can be achieved in over 80% of people with a diagnosis within the last 4 years and overweight or obesity by weight loss of 15 kg. The mechanisms involve an improvement of insulin sensitivity and thereby insulin requirements and a regain of the function of insulin secreting beta cells. Longer duration of type 2 diabetes appears to impair the capacity of beta cell to regenerate. At present it is not possibe to predict success of the weight loss at an early time point. The investigators therefore aim to identify early markers of responders. It is unclear how the weight loss induces the remission in responders. Immune cells are known to contribute to insulin resistance by regulating adipose tissue function and hepatic and skeletal muscle metabolism by releasing cytokines. The inborn immune system is known to adapt to external stimuli by the process of trained immunity and is thought to contribute to insulin resistance and the dysfunction of beta-cells. The investigation will analyze the programming state of innate immune cells in detail in the course of diabetes remission. In addition, islet hormone responses to challenge tests will be performed to assess their function in detail.
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Type 2 diabetes diagnosed less than 4 or over 8 years, before study,
BMI \> 28 kg/m²,
willingness to follow weight loss diet,
You may not be if
consuming disease,
intolerance for very low calorie formula diet,
known severe hepatic disease or liver cirrhosis,
type 1 diabetes,
severe disease of kidney or heart,
advanced diabetic retinopathy,
intake of glucocorticoids,
drug or alcohol abuse,
weight loss of \>5 kg in the last 3 month,
eating disorder
Clareo Health | Fasting-Associated Immune-metabolic Remission of Diabetes
