A Masked, Placebo-controlled Study to Assess Iptacopan in Age-related Macular Degeneration

Exclusion Criteria

• •History or current diagnosis of ECG abnormalities indicating significant safety risk, such as clinically significant cardiac arrhythmias, e.g., sustained ventricular tachycardia and clinically significant second or third degree atrioventricular block (AV block) without a pacemaker.
• •History of familial long QT syndrome or known family history of Torsades de Pointes
• •History of stroke or myocardial infarction during the 6-month period prior to Baseline/Day 1, any current clinically significant arrhythmias, or any advanced cardiac or severe pulmonary hypertension
• •History of end stage kidney disease requiring dialysis or renal transplant
• •History of malignancy of any organ system
• •History of solid organ or bone marrow transplantation
• •History of recurrent meningitis or history of meningococcal infections despite vaccination
• •History of immunodeficiency diseases, including a positive Human Immunodeficiency Virus test result at Screening
• •Active Hepatitis B (HBV) or Hepatitis C (HCV) infection
• •History of hypersensitivity to any of the study treatments or excipients or to drugs of similar chemical classes or clinically relevant sensitivity to fluorescein dye as assessed by the Investigator.
• •Evidence of cRORA or exMNV in the study eye based on multimodal imaging as determined by the central reading center.
• •Participants who have current active TB as evidenced by clinical, radiographic and laboratory tests.