A Study to Assess the Efficacy and Safety of HMI-115 in Subjects With Endometriosis-Associated Pain

Exclusion Criteria

• •1. Subject is pregnant or breastfeeding or is planning a pregnancy during the study period.
• •2. Subject has chronic pelvic pain that is not caused by endometriosis or has any other chronic pain syndrome or other chronic therapy, or that would interfere with the assessment of endometriosis-related pain
• •3. Subject has clinically significant gynecologic condition other than endometriosis
• •4. Subject has previous history of a severe, life-threatening or other significant sensitivity to any opioids or non-steroidal anti inflammatory drugs (NSAIDS) or any contraindication to their use such as gastrointestinal ulcer or bleeding
• •5. Subject has history of hysterectomy and/or bilateral oophorectomy
• •6. Subjects with past or present pituitary tumor growth
• •7. Subjects has a history of osteoporosis or other metabolic bone disease