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Correlation Between Brain Lesion and Continence in Children with Cerebral Palsy: an Anatomical MRI Study
More than 50 % of children and adults with cerebral palsy experience lower urinary tract symptoms (LUTS). This can negatively influence quality of life of the child and the total social environment. Previous research demonstrated that the brain lesion, characteristic for cerebral palsy (CP), is a prognostic factor for the functional abilities of a child with CP. Previous research within our department demonstrated functional impairment as a risk factor for incontinence. This demonstrates an indirect connection between the brain lesion and incontinence of a child with CP. However, this connection isn't alway correct as some children with high functionality also demonstrate incontinence. As bladder control is also regulated by higher brain centers, the present study wants to investigate a direct connection between the brain lesion of the child, visible by means of MRI, and the incontinence status of the child. .
The current study is a cross-sectional observational study in which a correlation is investigated between known anatomical MRI results and the continence status of a child with CP. Although neuroimaging isn't seen as a requirement for the definition and diagnosis of CP2, MRI imaging is often part of diagnostic evaluation. The Surveillance of Cerebral Palsy in Europe (SCPE) working group composed the MRI classification system or MRICS classifying neuroimaging results in maldevelopments, predominant white matter injury, predominant grey matter injury, miscellaneous and normal. These results will be correlated with results of the validated Vancouver symptoms score for dysfunctional elimination syndrome.
Age
5 - 12 years
Sex
ALL
Healthy Volunteers
No
Ghent University Hospital
Ghent, Flanders, Belgium
Start Date
October 25, 2021
Primary Completion Date
June 30, 2023
Completion Date
June 30, 2023
Last Updated
September 19, 2024
125
ACTUAL participants
Vancouver symptom score for dysfunctional elimination syndroms
OTHER
Magnetic resonance imaging
OTHER
Lead Sponsor
University Hospital, Ghent
Collaborators
NCT04630392
NCT07451548
NCT05901259
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