RanDOmized stUdy Comparing Both Latest Generation Self-Expanding Valves and a Minimalist approaCH vs. Standard Of Care In transCathEter Aortic Valve Implantation

Exclusion Criteria

• •Life expectancy \<12 months due to comorbidities
• •Native aortic valve annulus \<21 mm and \>27 mm
• •Bicuspid aortic valve
• •Cardiogenic shock or hemodynamic instability
• •Active endocarditis
• •Contraindications for transfemoral access
• •Active peptic ulcer or upper gastro-intestinal bleeding \<2 weeks
• •Hypersensitivity or contraindication to aspirin, heparin or clopidogrel
• •Contraindication for a specific treatment strategy (minimalist approach vs. standard of care) as judged by the Heart Team
• •Clear patient-specific clinical or anatomic reasons to prefer one treatment strategy or valve type over the other
• •Active infection requiring antibiotic treatment
• •Age \<18 years
• •Participation in another interventional trial where the primary endpoint has not been reached