TPO-RA in Primary Immune Thrombocytopenia (ITP) in Patients Older Than 14 Years

Inclusion Criteria

• •Men and women greater than or equal to 14 years of age.
• •Participants diagnosed with primary immune thrombocytopenia with two platelet counts of \< 30x10\^9/L or with bleeding at least 7 days apart，do not have evidence of other causes of thrombocytopenia (e.g.,pseudothrombocytopenia, myeloid fibrosis).
• •Previous treatment with poor response to first-line therapy and any of the maximum 4-week doses of eltrombopag, herombopag, avatrombopag, or 300U/kg/ day × 14-day rhTPO with no response to treatment (platelet count \< 30×109/L after treatment, or platelet count increase less than twice the baseline value, or with bleeding)
• •Participants willing and able to comply with the requirements of the study protocol, and sign the informed consent.