A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics ，Pharmacodynamics of Oral SHR2150 in Healthy Subjects

Exclusion Criteria

• •1. Currently suffering from cardiovascular, liver, kidney, digestive, nervous, blood, thyroid or mental diseases.
• •2. Have severe infection, severe trauma or major surgical operations within 3 months. Plan to receive surgery during the trial and within two weeks after the end of the trial..
• •3. 12-ECG test have clinical significant abnormality or the QT interval (QTc) \> 450 ms(male)/QTc)\> 460 ms(male) or\<300ms(female).
• •4. Screening for infectious diseases is positive (Including HBsAg, Anti-HCV, TPPA, Anti-HIV)
• •5. Suspected allergy to any ingredient in the study drug.
• •6. Have any drug that inhibits or induces liver metabolism within 1 month.
• •7. Any condition or disease that affects the absorption, metabolism, and/or excretion of the study drug judged by the investigator;
• •8. Treatment with immunosuppressant or interferon-containing drugs within 6 months of study drug administration;
• •9. Participated in clinical trials of any drug or medical device within 3 months before screening, or within 5 half-lives before screening;
• •10. Treatment with live(attenuated) vaccine within 2 months before taking the study drug or during the study or within 1 months after administration;
• •11. Had donated blood or blood transfusion≥ 200 mL within 1 months before taking the study drug or had donated blood or blood transfusion≥ 400 mL within 3 months prior to screening;
• •12. The average daily smoking ≥ 5 cigarettes within three months; the average daily alcohol intake in a month exceeds 15 g (15 g alcohol is equivalent to 450 mL beer or 150 mL wine or 50 mL low-alcohol);
• •13. Keep smoking, drinking alcohol or consuming caffeinated foods or beverages (more than 8 cups, 1 cup = 250 mL) 2 days before taking the study drug and during the study; and those who have special dietary requirements and cannot follow the unified diet;
• •14. History of drug abuse , drug dependence or drug screening test is positive;
• •15. Pregnant or lactating women;
• •16. Other conditions that the investigator believes the subject is not suitable.