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The purpose of this study is to examine how Bayesian belief updating changes throughout psychotherapeutic treatment for persecutory delusions. Specifically, individuals with a psychotic disorder diagnosis who endorse both a current persecutory delusion with strong conviction and significant worry will be recruited and randomized to receive either a CBT-based worry intervention for persecutory delusions or an active control condition (befriending therapy). The investigators will examine: 1) whether belief updating parameters change as delusion severity changes, 2) whether CBT contributes to greater change in belief updating parameters than befriending therapy, and 3) whether neural correlates of belief updating parameters, as measured using functional magnetic resonance imaging (fMRI), predict treatment response.
Age
18 - 65 years
Sex
ALL
Healthy Volunteers
No
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Start Date
March 30, 2021
Primary Completion Date
May 29, 2024
Completion Date
May 29, 2024
Last Updated
August 15, 2024
62
ACTUAL participants
Worry Intervention
BEHAVIORAL
Befriending
BEHAVIORAL
Lead Sponsor
Vanderbilt University Medical Center
NCT05759091
NCT04777266
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