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Screening for Colonization With Resistant Enterobacterales in Neutropenic Patients With Hematologic Malignancies (SCENE)
This is a prospective, observational cohort study to assess the frequency with which neutropenic patients with hematologic malignancies and hematopoietic cell transplant (HCT) recipients are colonized with fluoroquinolone-resistant Enterobacterales (FQRE) and the clinical impact of FQRE colonization.
This is a prospective, observational cohort study to assess the frequency with which neutropenic patients with hematologic malignancies and hematopoietic cell transplant (HCT) recipients are colonized with fluoroquinolone-resistant Enterobacterales (FQRE) and the clinical impact of FQRE colonization. The investigator will collect perianal swabs from patients receiving induction chemotherapy for acute leukemia or undergoing hematopoietic stem cell transplantation (HCT), and who are receiving fluoroquinolone (FQ) prophylaxis. FQRE colonization will be assessed by culture, and the investigator will correlate FQRE colonization with the risk of Gram-negative bacteremia during neutropenia. Population: 410 adults with acute leukemia who are receiving induction chemotherapy and HCT recipients who are receiving FQ prophylaxis during neutropenia. Results of this study will be combined with a portion of subject data from an identically-designed R01-funded study of FQRE colonization. The combined data will be used for study analysis and reporting.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
University of California San Fransisco Medical Center
San Francisco, California, United States
Hackensack Meridian Health
Nutley, New Jersey, United States
Mount Sinai Hospital
New York, New York, United States
University of North Carolina Chapel Hill
Chapel Hill, North Carolina, United States
Oregon Health and Science University
Portland, Oregon, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Start Date
March 12, 2021
Primary Completion Date
December 30, 2021
Completion Date
February 28, 2022
Last Updated
April 6, 2022
168
ACTUAL participants
No intervention.
OTHER
Lead Sponsor
Duke University
Collaborators
NCT05529069
NCT07257419
Data Source & Attribution
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