Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory

Study Description: The Behavioral Neurology Unit studies the human brain systems underlying learning and adaptation with the goal of finding interventions to make these processes more efficient. In this study, we are interested in examining how the task state of the episodic memory network influences the effect of faciliatory TMS on memory and its EEG neural correlates. It is hypothesized that Network-targeted parietal-TMS will improve memory performance and enhance EEG biomarkers of successful memory performance, but that these changes will be modulated by the ongoing task activity during stimulation. Objectives: Primary Objectives: Investigate how TMS modulates EEG neural measures of successful memory and the association of this modulation with behavioral performance Examine how memory task state influences susceptibility to plasticity via TMS and determine the optimal neural state for improving memory Exploratory Objectives: Search for MRI predictors of the effects of TMS Endpoints: Primary Endpoints: Memory performance, Late Positive Posterior ERP, evoked theta/alpha power (secondary), EEG functional connectivity (secondary) Exploratory Endpoints: fMRI resting state functional connectivity, fractional anisotropy