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Optimizing Exercise for the Treatment of Anxiety
90 sedentary adults with a primary anxiety disorder and high anxiety sensitivity will be randomized to either 8 weeks of 1) low intensity exercise, or 2) flexible titration to high intensity exercise (HIE). Blinded, validated clinician-rated and patient-rated outcomes will be assessed over treatment and at 1- and 3-month follow-up. To better understand what mechanisms influence decisions to exercise in the real-world, we will use of heart rate (HR) as an objective mechanistic target for exercise intensity, examine changes in valuation of exercise through a neuroeconomics task, examine changes in interoceptive sensitivity with a heartbeat detection task, and integrate of ecological momentary assessment (EMA) to measure effects of immediate changes in mood with exercise on anxiety outcomes and adherence.
Age
18 - 65 years
Sex
ALL
Healthy Volunteers
No
NYU Langone Health
New York, New York, United States
Start Date
June 30, 2021
Primary Completion Date
January 31, 2026
Completion Date
April 30, 2026
Last Updated
December 17, 2025
111
ESTIMATED participants
Titration to high intensity exercise (T-HIE)
BEHAVIORAL
Low intensity exercise prescription
BEHAVIORAL
Lead Sponsor
NYU Langone Health
NCT07478393
NCT07456631
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