Negative Pressure Applied by the Equinox MPD for Severe Open Angle Glaucoma

Inclusion Criteria

• •1. Male or female subjects ≥ 22 years of age at the time of signing the informed consent
• •2. Subjects willing to sign the informed consent and capable of committing to the study assessments
• •3. Subjects with orbital anatomy that permits a proper seal in both eyes when goggles are placed over eyes and can obtain IOP measurements with Excursion goggles in place
• •4. Subjects with a diagnosis of severe open-angle glaucoma (OAG definition is inclusive of primary open angle glaucoma, normal tension glaucoma, pseudoexfoliative glaucoma, and pigmentary glaucoma) in at least one eye, defined by glaucomatous optic disc or RNFL abnormalities AND visual field abnormalities in both hemifields and/or loss within 5 degrees of fixation in at least one hemifield as tested with standard automated perimetry (the diagnosis of the contralateral eye may include suspected OAG\< as well as mild/moderate/severe OAG)
• •5. Subjects with treatment regimens including current ocular hypotensive medications, prior non-incisional surgical procedures (e.g. MIGS and SLT), or any combination of the two
• •6. Subjects who are literate, able to speak English or Spanish, and able to understand and follow study instructions