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A Pilot of Metformin Postpartum
The overall goal of this proposal is to assess metformin initiation at the time of hospital discharge for women with a history of gestational diabetes mellitus (GDM) improves maternal health at 1 year post-partum. Our central hypothesis is that diabetes mellitus (DM) prevention with metformin can be initiated days after delivery, rather than months to years after delivery, and result in a pragmatic and efficacious means of preventing DM and improving weight loss over the first year post-partum. To test this hypothesis, we will perform a open-label randomized controlled trial of metformin compared to placebo routine care initiated at the time of hospital discharge in women with a history of GDM.
Age
18 - 50 years
Sex
FEMALE
Healthy Volunteers
Yes
Women & Infants Hospital
Providence, Rhode Island, United States
Start Date
November 15, 2020
Primary Completion Date
October 31, 2021
Completion Date
June 30, 2022
Last Updated
November 4, 2020
200
ESTIMATED participants
Metformin
DRUG
Lead Sponsor
Women and Infants Hospital of Rhode Island
NCT06648174
NCT06948825
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