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AK104 in Locally Advanced MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer | Clinical Trials | Clareo Health

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AK104 in Locally Advanced MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer

A Multicenter, Open-Label, Phase II Study of Anti-PD-1/CTLA-4 Bispecific Antibody AK104 in the Perioperative Treatment of Locally Advanced Microsatellite Instability/Mismatch Repair Protein-Deficient Gastric and Colorectal Cancers

NCT04556253•Peking University

View on ClinicalTrials.gov

Summary

This is a single-arm, multicenter phase II clinical study. The aim is to evaluate the safety, tolerability, and anti-tumor activities of AK104(a PD-1/CTLA-4 bispecific antibody) in MSI-H/dMMR locally advanced gastric adenocarcinoma and colorectal cancer during the perioperative period.Eligible patients will receive AK104 for three cycles before surgery and at most 6 months after surgery. The primary endpoint is the pathological complete response rate.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Written and signed informed consent.
•Eastern Cooperative Oncology Group (ECOG) Performance Score of 0 or
•The estimated life expectancy of ≥3 months.
•Confirmed MSI-H/dMMR status by the central laboratory.
•For cohort 1, histologically or cytologically documented locally advanced gastric carcinoma(cT3-T4a, Nx, M0). For cohort 2, histologically or cytologically documented locally advanced colorectal cancer(cT2-T4a, Nx, M0).
•Haven't received any chemotherapy or radiotherapy.
•Adequate organ function.
•All female and male subjects of reproductive potential must agree to use an effective method of contraception, as determined by the Investigator, during and for 120 days after the last dose of study treatment.

Exclusion Criteria

•Is currently participating in a study of an investigational agent or using an investigational device;
•Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy within 2 years prior to the first dose of study treatment;
•Has undergone major surgery within 30 days of Study Day 1;
•Has a known additional malignancy that is progressing or requires systemic treatment. Exceptions include basal cell carcinoma of the skin, squamous cell carcinoma of the skin that has undergone potentially curative therapy or in situ cervical cancer.
•Has known active central nervous system (CNS) metastases;
•Has carcinomatous meningitis;
•Has an active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment NOTE: Subjects with vitiligo or resolved childhood asthma/atopy would be an exception to this rule. Subjects that require intermittent use of bronchodilators or local steroid injections would not be excluded from the study;
•Has an active infection requiring systemic therapy;
•Has known active Hepatitis B (e.g., HBsAg reactive) or Hepatitis C (e.g., HCV RNA \[qualitative\] is detected);
•History of myocardial infarction, unstable angina, cardiac or other vascular stenting, angioplasty, or surgery within 12 months prior to day 1 of study treatment;
+5 more criteria

Locations (1)

Peking University Cancer Hospital & Institute

Beijing, Beijing Municipality, China

Key Dates

Start Date

February 28, 2024

Primary Completion Date

December 1, 2026

Completion Date

December 1, 2028

Last Updated

January 2, 2026

Enrollment

ESTIMATED participants

Conditions

MSI-H/dMMR Gastric Carcinoma and Colorectal Cancer

Interventions

AK104

DRUG