A Trial of HR18034 in Inguinal Hernia Repair

Exclusion Criteria

• •1. Clinically significant abnormal clinical laboratory test value
• •2. Subjects with poor blood pressure control after medication
• •3. Subjects with atrioventricular block or cardiac insufficiency
• •4. Subjects with a history of myocardial infarction or unstable angina pectoris
• •5. Subjects with a history of ischemic stroke or transient ischemic attack
• •6. Combination of other pain conditions that may affect postoperative pain assessment
• •7. Allergic to a drug ingredient or component
• •8. Persistent or recurrent nausea and/or vomiting due to other etiologies, including, but not limited to gastric outlet obstruction, hypercalcemia, or active peptic ulcer
• •9. History of alcohol abuse or prescription and/or illicit drug abuse within 1 years
• •10. Subjects with special diets (including tobacco, grapefruit and caffeine)
• •11. Positive results on the urine drug screen or alcohol breath test indicative of illicit drug or alcohol abuse.
• •12. History of human immunodeficiency virus (HIV), hepatitis C, syphilis antibody，or hepatitis B.
• •13. Use of any of the following medications within 14 days or as specified prior to the study surgical procedure:
• •14. Have had an inguinal hernia repair in the last 3 months before the study surgical procedure or presents with bilateral or recurrent inguinal hernia, other hernia presentations, or hernias with a large scrotal component that would be difficult to reduce surgically
• •15. Participated in clinical trials of other drugs (received experimental drugs)
• •16. History or clinical manifestations of significant renal, hepatic, gastrointestinal, cardiovascular, metabolic, neurologic, psychiatric, or other condition.
• •17. Pregnant or nursing women
• •18. No birth control during the specified period of time
• •19. The inestigators determined that other conditions were inappropriate for participation in this clinical trial