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Comparison of Dimensional Changes After Tooth Extractions Between Xenograft and Allograft | Clinical Trials | Clareo Health

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Comparison of Dimensional Changes After Tooth Extractions Between Xenograft and Allograft

A Pilot RCT Study Comparing Dimensional Alterations After Socket Grafting With Xenograft Versus Allograft

NCT04550689•UConn Health

View on ClinicalTrials.gov

Summary

To compare dimensional changes in extraction socket of single rooted teeth, 6 months post extraction, when grafted with xenograft versus allograft.

Detailed Description

AIM To compare dimensional changes in extraction socket of single rooted teeth, 6 months post extraction, when grafted with xenograft versus allograft. PRIMARY OBJECTIVE Horizontal and vertical dimensional changes of extraction sockets as evaluated in a CBCT scan immediately post extraction and 6 months post extraction when grafted with xenograft versus allograft. SECONDARY OBJECTIVE 1. Difference in horizontal dimensional changes in xenograft and allograft groups as measured intra-operatively after extraction and at re- entry 6 months post extraction. 2. Difference in vertical dimensional changes in xenograft and allograft groups as measured intra-operatively after extraction and at re- entry 6 months post extraction. 3. Difference in histologic analysis of bone biopsy cores taken in xenograft and allograft groups at 6 months re-entry from osteotomy site. Difference in newly regenerated supracrestal bone height and volume will be measured directly from the segmented images from MicroCT. NULL HYPOTHESIS There is no difference between the two groups for any of the parameters evaluated.

Eligibility

Age

21 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•1. Males or females ≥ 21 years of age
•2. Able to provide informed consent
•3. Good general oral health (no active periodontal disease, absence of hopeless teeth, absence of active caries, absence of acute infections)
•4. Single rooted non molar teeth needing extraction for miscellaneous reasons (since histological analysis is being done, it is essential to harvest bone core biopsies without inclusion of native bone16)
•5. Presence of natural teeth adjacent to the tooth planned for extraction
•6. Absence of acute signs of infection such as pus discharge, fistulous tract and / or abscess in relation to tooth being extracted
•7. Dehiscence type defects of the sockets limited to 2/3rd length of the root

Exclusion Criteria

•Systemic conditions
•1. Conditions and circumstances as evaluated by investigator that would prevent completion of study participation
•2. Conditions requiring chronic routine use of antibiotics or steroids
•3. History of leukocyte dysfunction or deficiencies, bleeding disorders, neoplastic disease requiring radiation or chemotherapy, metabolic bone disorder, uncontrolled endocrine disorders, HIV infections
•4. Alcoholism or drug abuse and heavy smokers \>10 cigarettes a day
•5. Simultaneous participation in other studies
•6. Pregnancy - Patients pregnant before the start of the study or patients who become pregnant during the course of the study
•Local conditions
•1. Untreated periodontitis, caries or presence of hopeless teeth (other than the one planned for extraction)
•2. Multi rooted teeth
+5 more criteria

Locations (1)

UConn Health

Farmington, Connecticut, United States

Key Dates

Start Date

October 1, 2020

Primary Completion Date

June 30, 2023

Completion Date

June 30, 2024

Last Updated

November 28, 2023

Enrollment

ESTIMATED participants

Conditions

Tooth Loss

Interventions

Bone graft

DEVICE

Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites

NCT07177521

Edentulous JawTooth Loss+1 more

View study

RECRUITING

DEntal implaNt Set: Development and Implementation of a Standardized Outcome Set in Implant Dentistry

NCT07337057

Tooth Loss / Rehabilitation

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 28, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Comparison of Dimensional Changes After Tooth Extractions Between Xenograft and Allograft

Inclusion Criteria

Exclusion Criteria

Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites

DEntal implaNt Set: Development and Implementation of a Standardized Outcome Set in Implant Dentistry

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Primary and Secondary Elevations of Maxillary Sinuses: a Prospective Clinical Study in the Posterior Maxillary Region

Evaluation of Mandibular Posterior Zirconia Crowns With Different Ti-Base Surface Treatments.