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Lead
Yale University
With
National Institute of Mental Health (NIMH)
This study is an extension of previous clinical trials (NCT00308997 and NCT00567281) that were initiated in 2006. This study record provides the results for the amended study NCT00567281 (originally called a 'third arm') that was discontinued following the passing of Dr. Ralph Hoffman. The primary purpose of the study was to conduct fMRI neuroimaging studies prior to and subsequent to the rTMS intervention. The intent was to ascertain changes in regional brain activation and connectivity that most robustly predict level of improvement in auditory hallucinations elicited by bilateral rTMS as assessed by our primary outcome variables. It was hoped that this combined fMRI/rTMS study would provide critical new insights into the neurobiological basis of auditory hallucinations.
The results presented are what was summarized following Dr. Hoffman's passing and were compiled by Dr. Philip Corlett.
Age
18–55
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Previously enrolled in our "parent" rTMS trial with passage of at least six months since last received active rTMS
You may not be if
Active substance abuse or alcohol abuse
Pregnancy
Dose or type of psychiatric medication changed within the 4 weeks prior to study entry
Recent head trauma, seizures, or significant unstable medical condition
Clareo Health | Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Results