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COMPLETEDNA

Blood Pressure Management on Cardiovascular AdveRse Events After Major Abdominal Surgery

Blood Pressure Management on Cardiovascular AdveRse Events After Major Abdominal Surgery (BP-CARES): A Randomized Controlled Trial

NCT04430920•Nanfang Hospital, Southern Medical University

View on ClinicalTrials.gov

Summary

This study is a multicenter randomized controlled trial comparing an intensive intraoperative blood pressure management strategy versus conventional practice for preventing cardiovascular events in high-risk patients undergoing major abdominal surgery.

Detailed Description

Intraoperative hypotension has been associated with cardiovascular events after non-cardiac surgery. However, whether avoiding intraoperative hypotension can reduce the incidence of postoperative cardiovascular events remains unclear. The objective of this study is to assess the effects of an intensive intraoperative blood pressure management strategy (to maintain intraoperative MAP ≥ 80mmHg) with that of conventional practice (to maintain intraoperative MAP ≥ 65mmHg) on the incidence of cardiovascular events after major abdominal surgery.

Eligibility

Age

45 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Aged ≥ 45 years;
•2. Undergoing major abdominal surgery under general anesthesia (expected surgery time \>2h, expected length of postoperative stay \>2d);
•3. Fulfill ≥1 of the following criteria (a-f): a. history of coronary artery disease; b. history of stroke; c. history of peripheral arterial disease; d. history of congestive heart failure; e. preoperative NT-proBNP \>200 pg/mL or BNP \>92 mg/L f. preoperative troponin \> upper limit of normal; or fulfill ≥2 of the following criteria (g-l); g. history of chronic kidney disease (preoperative sCr \>133μmol/L or 1.5 mg/dL); h. diabetes requiring medical treatment; i. smoking in the past \>2 years; j.≥ 65 years of age; k. hypertension requiring medical treatment l. history of hypercholesterolemia.

Exclusion Criteria

•1. ASA score ≥5;
•2. Severe untreated or uncontrolled hypertension (preoperative SBP\>180mmHg and/or DBP\>110mmHg);
•3. End-stage renal disease requiring renal-replacement therapy;
•4. Acute cardiovascular event within 1 month of surgery, including acute heart failure, acute coronary syndrome and stroke;
•5. Preoperative sepsis or septic shock;
•6. Preoperative requirement of vasopressor infusion;
•7. Current participation in another interventional study;
•8. Previous participation in this study;
•9. Pregnant or breastfeeding women.

Locations (3)

Xinqiao Hospital of Chongqing

Chongqing, Chongqing Municipality, China

Southern Medical University Nanfang Hospital

Guangzhou, China

Henan Provincial People's Hospital

Zhengzhou, China

Key Dates

Start Date

June 30, 2020

Primary Completion Date

September 23, 2022

Completion Date

April 8, 2025

Last Updated

April 22, 2025

Enrollment

1,500

ACTUAL participants

Conditions

Cardiovascular Complication

Interventions

Intensive intraoperative blood pressure management

OTHER

Conventional intraoperative blood pressure management

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 22, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Blood Pressure Management on Cardiovascular AdveRse Events After Major Abdominal Surgery

Inclusion Criteria

Exclusion Criteria

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