Loading clinical trials...

Evaluating Effects of Curcumin in Moderate to Severe Asthmatics | Clinical Trials | Clareo Health

WITHDRAWNPHASE2

Evaluating Effects of Curcumin in Moderate to Severe Asthmatics

Evaluating the Effects of Curcumin in Moderate to Severe Asthmatics

NCT04353310•Loma Linda University

Summary

The purpose of this investigator-initiated study is to evaluate the effects of oral curcumin supplementation versus placebo in adult patients with moderate to severe asthma. Curcumin, a derivative of turmeric, has been shown in animal models to inhibit the secretion of pro-inflammatory cytokines and decrease airway constriction and hyperreactivity with only a few observational studies available in humans with discordant results.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Provision of signed and dated informed consent form
•2. Stated willingness to comply with all study procedures and availability for the duration of the study
•3. Male or female, aged 18 and older
•4. Physician diagnosed moderate to severe asthma: (GINA 2018)
•a. Stable asthma that requires ICS/LABA and/or an additional controller agent (i.e. LTRA, LAMA)
•5. Ability to take oral medication and be willing to adhere to the regimen
•6. Ability to speak and read English
•7. If female and sexually active, should use effective forms of birth control

Exclusion Criteria

•1. Current use of turmeric (curcumin) or use within the last 7 days
•2. Current use of biologic therapy/ immunotherapy/ or bronchothermoplasty
•3. Pregnancy or lactation
•4. Known allergic reactions to components of turmeric (curcumin)
•5. Current use of anticoagulants, and history of coagulopathy or liver disease
•6. INR greater than 2.0, PTT greater than 45.0 seconds

Key Dates

Start Date

September 1, 2021

Primary Completion Date

November 9, 2021

Completion Date

November 9, 2021

Last Updated

November 17, 2021

Conditions

Asthma

Interventions

Curcumin

DRUG

Placebo

OTHER

A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

NCT07219173

Asthma

View study

RECRUITING

NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)

NCT02327897

Asthma

View study

RECRUITINGNA

Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM)

NCT07486401

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 17, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Evaluating Effects of Curcumin in Moderate to Severe Asthmatics

Inclusion Criteria

Exclusion Criteria

A Study to Evaluate Brenipatide Compared With Placebo in Adult Participants With Uncontrolled Moderate to Severe Asthma

NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)

Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM)

Relationship of Airway Microbiota, Endotype and Phenotype in Adult Asthma

To Assess the Management of Patients on Global Initiative of Asthma (GINA) Step 4 and 5 Treatment in Hong Kong

A Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic Chinese Adults With Asthma