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The Microcirculatory Characteristics of the Heart and Lung Meridians: A Study of CSAP Patients and Healthy Adults | Clinical Trials | Clareo Health

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The Microcirculatory Characteristics of the Heart and Lung Meridians: A Study of CSAP Patients and Healthy Adults

NCT04244812•Zhejiang Chinese Medical University

View on ClinicalTrials.gov

Summary

This study is designed to detect the microcirculatory characteristics of meridian phenomena by using an objective assessment tool and investigate the site specificity for the meridian-visceral association and surface-surface association between two specific meridians.

Detailed Description

The Lung and Heart meridians are chosen as two specific studied meridians. Participants of chronic stable angina pectoris (CSAP) and healthy volunteers will be enrolled. 120 participants will be included and divided into the healthy control group, chronic stable angina pectoris (CSAP) group and healthy intervention group. Laser doppler flowmetry (LDF) will be used to assess the microcirculatory characteristics of meridian phenomena for the Heart and Lung meridians. The site specificity for the meridian-visceral association will be investigated by comparing the microcirculatory difference between the Heart and Lung meridians in the healthy control group and CSAP group. Besides, participants in the healthy intervention group will receive two sessions of moxibustion in the Heart meridian and Lung meridian respectively to explore the site specificity for the surface-surface association.

Eligibility

Age

20 - 75 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Patients should meet the diagnostic criteria of coronary heart disease, which includes the following items: 1)confirmed old myocardial infarction (MI), or a history of percutaneous coronary intervention(PCI), or coronary artery bypass grafting; 2)50% or more luminal stenosis in at least one coronary artery or major branch segment confirmed by coronary angiogram or CT angiography; 3) myocardial ischemia indicted by exercise stress radionuclide myocardial imaging; 4) treadmill exercise testing is positive (for male patients);
•Patients should meet the diagnostic criteria of CSAP and the Canadian Cardiovascular Society(CCS) classification for CSAP is level II or III;
•The medical history of CSAP is more than 3 months with attacks occurring at least twice weekly in the last month;
•35 ≤ age ≤75 years, male or female;
•Patients have clear consciousness and could communicate with others normally;
•Patients could understand the full study protocol and written informed consent is signed.
•Healthy volunteers should provide a recent medical examination report to confirm they have not any cardiovascular, respiratory, digestive, urinary, hematological, endocrine and neurological disease;
•age≥20 years, male or female;
•Participants have clear consciousness and could communicate with others normally;
•Participants could understand the full study protocol and written informed consent is provided by themselves or their lineal kin.

Exclusion Criteria

•Patients with acute coronary syndrome and severe arrhythmias;
•Patients'chest pain is caused by valvular heart disease, hypertrophic cardiomyopathy and dilated cardiomyopathy;
•Patients'chest pain is caused by non-cardiac disease;
•Patients have concomitant conditions of lung diseases, such as obstructive pulmonary disease;
•Patients have serious concomitant conditions and fail to treat them effectively, such as diseases of the digestive, urinary, respiratory, hematological and nervous system;
•Patients have mental illness, severe depression, alcohol dependence or history of drug abuse;
•Pregnant or lactating patients;
•Patients are participating in other trials.
•Participants have mental illness, severe depression, alcohol dependence or history of drug abuse;
•Pregnant or lactating participants ;
+1 more criteria

Locations (1)

the Third affiliated hospital of Zhejiang Chinese Medical university

Hanzhou, Zhejiang, China

Key Dates

Start Date

February 1, 2020

Primary Completion Date

December 31, 2020

Completion Date

December 31, 2021

Last Updated

January 30, 2020

Enrollment

120

ESTIMATED participants

Conditions

Chronic Stable Angina Pectoris

Interventions

Moxibustion

OTHER

Laser doppler flowmetry

DEVICE

Contacts

Yongliang Jiang, M.D

CONTACT

86-13858173136 jyl2182@126.com

Hantong Hu

CONTACT

86-18667103032 413351308@qq.com