Sintilimab (IBI308) Combined With Bevacizumab + XELOX Regimen in Metastatic Colorectal Cancer

Inclusion Criteria

• •1. Male or female, age ≥ 18 years old, ≤ 75 years old;
• •2. Metastatic colorectal adenocarcinoma confirmed by histology and unresectable metastatic colorectal cancer confirmed by a multidisciplinary team;
• •3. RAS gene mutation, BRAF wild-type and microsatellite stable confirmed by polymerase chain reaction using a panel of six mononucleotide repeat markers (BAT-25, BAT-26, NR-21, NR-24, NR-27, and MONO-27);
• •4. ECOG performance status of 0-1;
• •5. Life expectancy≥3 months;
• •6. Adequate organ and bone marrow functions: absolute neutrophil count \>1.5×109/L, hemoglobin \>8 g/dL, platelet count \>100×109/L, prothrombin time \<1.5 upper limit of normal (ULN), activated partial thromboplastin time \<1.5 ULN, bilirubin ≤1.5×ULN (could be extended to 3×ULN in case of liver metastasis), blood aspartate aminotransferase and alanine aminotransferase ≤2.5×ULN (could be extended to 5×ULN in case of liver metastasis), serum creatinine level ≤1.5×ULN or creatinine clearance ≥50 mL/min, urinary protein / creatinine ratio \< 1 (or urine analysis \< 1 + or 24-hour urinary protein \< 1g / 24 h;
• •7. Informed consent has been signed;
• •8. The presence of at least one measurable lesion assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1;