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Two important mechanisms play a major role in the pathogenesis of type 2 diabetes: insulin resistance of the target tissues and the impaired insulin secretion from pancreatic β-cells. Postprandial factors (such as insulin) are perceived by the human brain and induce signals that regulate glucose metabolism via the parasympathetic nervous system. Deep breathing exercise can increase parasympathetic nerve activity. Heart rate variability (HRV) in healthy people can be significantly increased by deep breathing maneuvers, indicating a shift from sympathetic activity to parasympathetic activity. The hypothesis is that this postprandial shift results in a change in peripheral glucose metabolism. In turn, the increased parasympathetic activity could potentially result in a change in postprandial insulin sensitivity or secretion. To test this hypothesis, this study investigates the effect of deep breathing exercise versus normal breathing on insulin sensitivity, on insulin secretion, glucose tolerance, resting energy expenditure, and on parasympathetic tone (analysis of heart rate variability).
Age
18 - 65 years
Sex
MALE
Healthy Volunteers
Yes
University of Tuebingen, Department of Internal Medicine IV
Tübingen, Germany
Start Date
November 1, 2019
Primary Completion Date
March 1, 2020
Completion Date
April 1, 2020
Last Updated
June 17, 2020
16
ACTUAL participants
deep breathing
OTHER
Lead Sponsor
University Hospital Tuebingen
NCT07482930
NCT06688461
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