The OPTIMAL Randomized Controlled Trial

Exclusion Criteria

• •1. Patient is a woman who is pregnant or nursing;
• •2. Female patient of childbearing potential, i.e. who are not surgically sterile or post-menopausal (defined as no menses for 2 years without an alternative cause);
• •3. IVUS is strictly required for pre-PCI lesion severity assessment
• •4. ST-elevation myocardial infarction, cardiogenic shock;
• •5. Previous history of CABG with patent graft to the LAD and/or patent graft to the LCX;
• •6. Prior PCI of the LM, ostial LAD or ostial LCX at any time prior to enrollment;
• •7. Prior PCI of any other (i.e. non-LM, non-ostial-LAD and non-ostial-LCX) coronary artery lesions within 30 days prior to enrollment;
• •8. Patients unable to tolerate, obtain or comply with dual antiplatelet therapy for at least 6 months in stable patients and 1 year in ACS patients;
• •9. Known contraindication or hypersensitivity to everolimus, platinum-chromium, or to anticoagulants.
• •10. Patients requiring additional surgery (cardiac or non-cardiac) within 3 months post-enrollment;
• •11. Non-cardiac co-morbidities with a life expectancy less than 2 years;
• •12. Currently participating in another trial that is not yet at its primary endpoint. The patient is not allowed to participate in another investigational device or drug study for at least 12 months after enrollment.