Agnieszka Glazewska-Hallin

CONTACT

Michael Waring

CONTACT

Lead Sponsor

Guy's and St Thomas' NHS Foundation Trust

Collaborators

Age

16 - No limit years

Sex

FEMALE

Healthy Volunteers

Yes

•CRAFT-OBS
•Pregnant women under 23+6 weeks gestation with a history of previous caesarean section in labour.
•Singleton pregnancy.
•Willing and able to give informed consent (with or without interpreter).
•Pregnant women up to 23+6 weeks gestation with a history of FDCS.
•Short cervix (\<=25mm) on transvaginal ultrasound scan.
•Pregnant women between 14+0 and 23+6 weeks gestation with a history of FDCS.

•Under 16 years of age.
•Inability to give informed consent.
•Previous caesarean section carried out before labour.
•Women who have been commenced on management with progesterone, a cerclage or arabin pessary as part of their care or another research study
•CRAFT-RCT:
•Women with persistent fresh vaginal bleeding evident on speculum examination.
•Women with visible fetal membranes evident on speculum examination or open cervix on ultrasound scan.
•Women with severe abdominal pain/evidence of sepsis (as judged by attending clinician).
•Known significant congenital or structural or chromosomal fetal abnormality.
•Suspected or proven rupture of the fetal membranes at the time of recruitment.
•CRAFT-IMG
•Contraindications to MRI, e.g. claustrophobia, BMI \>40 kg/m2 (due to technical limitations of scanner) or a women with a non-MRI compatible metallic implant.