HFNC and Acute Hypercapnic Respiratory Failure

High Flow Nasal Oxygen Therapy in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hypercapnic Respiratory Failure (AHRF)

NCT04109560•Argentinian Intensive Care Society

View on ClinicalTrials.gov

Summary

High-flow nasal cannula (HFNC) enables delivering humidified gas at high-flow rates controlling the oxygen inspired fraction (FiO2). Its efficacy has been demonstrated in hypoxemic acute respiratory failure. However, little is known about its use in hypercapnic acute respiratory failure (ARF). Therefore, we aimed to evaluate the effect of using HFNC through "Precision Flow" equipment as first line of ventilatory support for COPD patients with hypercapnic acute respiratory failure.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Moderate to very severe COPD patients (GOLD 2 to 4) over 18 years old admitted to the ICU with hypercapnic ARF (PaCO2\> 45 mmHg and respiratory acidosis \[pH ≥7.30\], with or without hypoxemia + one of the following: Respiratory Rate ≥25 cycles per minute, intercostal and / or supraclavicular recruitment, or thoraco-abdominal synchrony, no prior use of NIV)

Exclusion Criteria

•Patients less than 18 years old
•Mild COPD patients
•Absence of hypercapnia
•Kelly M Score \> 3
•Haemodynamic instability (despite fluid resuscitation)
•NIV or Invasive Mechanical Ventilation (IMV) (Need to use previously to HFNC)
•Contraindications to implement high-flow oxygen therapy.

Locations (1)

Sanatorio Anchorena

CABA, Argentina

Key Dates

Start Date

August 1, 2018

Primary Completion Date

September 30, 2019

Completion Date

September 30, 2019

Last Updated

October 23, 2019

Enrollment

ACTUAL participants

Conditions

High Flow Oxygen TherapyAcute Hypercapnic Respiratory FailureCOPD Exacerbation

Emotional-distress-based Integrated Care Programme in Patients With an Acute Exacerbation of COPD

NCT07351929

COPD Exacerbation

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RECRUITINGNA

High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease

NCT03033251

Exacerbation CopdAcute Respiratory Distress+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 23, 2019Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

HFNC and Acute Hypercapnic Respiratory Failure

Inclusion Criteria

Exclusion Criteria

Emotional-distress-based Integrated Care Programme in Patients With an Acute Exacerbation of COPD

High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease

Impact of Continuous Positive Airway Pressure on the Occurrence of Acute Exacerbations of COPD in Patients With COPD-OSA Overlap Syndrome (CO-OS)

Pilot Physiological Evaluation of an Investigational Mask with Expiratory Washout.

Supported Rescue Packs Post-discharge in Chronic Obstructive Pulmonary Disease

Nasal High-Flow in COPD