Hepcidin Mimetic in Patients With Polycythemia Vera (REVIVE)

Inclusion Criteria

• •1. Male and female subjects aged 18 years or older.
• •2. Meet revised 2016 World Health Organization (WHO) criteria for the diagnosis of polycythemia vera.
• •3. Records of all phlebotomies performed for at least 28 weeks (preferably up to 52 weeks) before dosing are available.
• •4. Subjects who are not receiving cytoreductive therapy must have been discontinued from any prior cytoreductive therapy for at least 24 weeks before screening and have recovered from any adverse events due to cytoreductive therapy.
• •5. Subjects receiving cytoreductive therapy with hydroxyurea, interferon, or ruxolitinib must have received cytoreductive therapy for at least 24 weeks and be on a stable dose or have a decreasing dose (Medical Monitor approval required) for at least 8 weeks before dosing and with no planned change in dose.