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The pathophysiological characteristics of COPD is irreversible airflow restriction which may influence the gas exchange and cause the abnormal PaO2 and PaCO2. Assessment of the partial arterial pressure of carbon dioxide (PaCO2 ) is the 'gold standard' for the evaluation of the adequacy of alveolar ventilation.Method used mostly nowadays : arterial puncture which is accurate but is invasive 、painful、 non-dynamic and there is risk of infection and tissue、nerve damage. Noninvasive measurement methods (Most commonly used): end-tidal CO2( ETCO2)、 transcutaneous CO2(TcCO2). They all can monitor the PaCO2 dynamically、 noninvasively, but is existence of controversy of the accuracy. So the investigators want to compare the accuracy of these two noninvasive methods for assessment of PaCO2.
Age
20 - 100 years
Sex
ALL
Healthy Volunteers
No
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
Start Date
August 10, 2019
Primary Completion Date
June 1, 2020
Completion Date
June 1, 2020
Last Updated
October 23, 2019
100
ESTIMATED participants
Lead Sponsor
The First Affiliated Hospital of Guangzhou Medical University
NCT07477600
NCT07462221
NCT07351929
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