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Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies | Clinical Trials | Clareo Health

UNKNOWNPHASE4

Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies

Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies--A Multicenter, Prospective, Open, Randomized, Controlled Clinical Trial

NCT04051567•Ministry of Science and Technology of the People´s Republic of China

View on ClinicalTrials.gov

Summary

Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth. Low-dose aspirin was recommend by American College of Obstetricians and Gynecologists (ACOG) during pregnancy. In this trial, the investigators suppose that aspirin used in twin-pregnancies could improve adverse pregnancy outcomes.

Eligibility

Age

18 - 55 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•Twin pregnancy diagnosed by ultrasound and maternal age ranged from 18 to 55 years, Gestational age was less than 16w

Exclusion Criteria

•Diagnosed fetal anomalies, history of cervical cerclage, contraindications of aspirin, pre-existing renal or liver diseases or abnormal functions, coagulation disorders, history of PE, preterm birth or FGR, chronic hypertension

Locations (1)

Hongbo,Qi

Chongqing, Chongqing Municipality, China

Key Dates

Start Date

November 1, 2018

Primary Completion Date

June 1, 2020

Completion Date

December 1, 2020

Last Updated

October 29, 2019

Enrollment

425

ESTIMATED participants

Conditions

Twin PregnancyPreeclampsiaPreterm BirthFetal Growth Restriction

Interventions

Aspirin 100mg

DRUG

Prevention of Preeclampsia in Denmark: A National Implementation Study

NCT07485140

Preeclampsia (PE)

View study

RECRUITINGEARLY_PHASE1

Vascular Effects of High-Salt After Preeclampsia

NCT06749418

PreeclampsiaPreeclampsia Postpartum

View study

RECRUITINGNA

Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 29, 2019Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies

Inclusion Criteria

Exclusion Criteria

Prevention of Preeclampsia in Denmark: A National Implementation Study

Vascular Effects of High-Salt After Preeclampsia

Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy

Stress Phenotypes and Preterm Birth

A Study to Investigate the Safety, Pharmacodynamic and Pharmacokinetic Characteristics of CBP-4888 in Hospitalized Participants With Preterm Preeclampsia and Their Children up to 24 Months

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL