Time Restricted Feeding and Metabolic Rhythms

Exclusion Criteria

• •Subjects must not be currently participating in another research study that would influence their safe participation in this study. For example, subjects must not be participating in a research study in which they ingest experimental medication, or which involves blood samples, since both of these factors could increase risk of participation;
• •Being considered unsafe to participate as determined by the study physician;
• •Taking medications affecting weight, triglycerides, energy intake/energy expenditure, or sleep in the last 3 months;
• •Having abnormal blood chemistry and/or hematology as deemed significant by the study physician;
• •o Have one or more of the following out-of-range values measured on a fasting blood sample: glucose \> 126 mg/dl, HbA1c \> 6.5%, thyroid stimulating hormone \<0.5 or \>5.0 uU/ml. Subjects who may be anemic (hemoglobin \<14.5 g/dl men, \<12.3 g/dl women), have abnormal liver function tests (alanine amino transferase \> 47 U/l, aspartate aminotransferase, \> 47 U/l, alkaline phosphatase \<39 or \>117 U/l) or creatinine (\>1.1 mg/dl)
• •Significant abnormality in clinical laboratory values
• •Ever having a history of systemic, psychiatric, neurological disease, or drug and alcohol abuse;
• •History of cardiovascular disease, diabetes, uncontrolled hypertension, untreated thyroid, renal, hepatic diseases, dyslipidemia or any other medical condition affecting weight or lipid metabolism;
• •Score \> 18 on Beck Depression Index (BDI) will require further assessment by the study physician to determine if it is appropriate for the subject to participate in the study;
• •Use of a continuous positive airway pressure (CPAP) device for the treatment of obstructive sleep apnea (OSA). A score of \>10 on the Epworth sleepiness scale or \>5 on the Pittsburgh Sleep Quality Index will require further assessment by the study physician to determine if it is appropriate for the subject to participate in the study;
• •Being positive for human immunodeficiency virus or hepatitis B or C;
• •Being a smoker or having been a smoker in the previous 6 months;
• •Abnormal eating patterns identified by registered dietician interview (dietary fat\<15%, dietary fat\>45%, dietary protein \>30%);
• •Working night shifts;
• •Night eating syndrome (at least 25% of food intake is consumed after the evening meal and/or at least two episodes of nocturnal eating per week);
• •Traveling \> 2 time zones 2 weeks prior to an inpatient CTRC study visit;
• •Currently participating in any formal weight loss or physical activity programs or clinical trials.
• •Having a clinically significant allergy (e.g., to food stuffs such as shellfish, peanuts);
• •Celiac disease or known sensitivity to gluten (the metabolic kitchen is not gluten free certified and cannot accommodate this dietary restriction)