Lead Sponsor

Boston University

Collaborators

Age

0 - 5 years

Sex

ALL

Healthy Volunteers

No

•In order to be eligible to participate in this study, an individual must meet all of the following criteria:
•Pediatric patients aged between 2 months and 5 years presenting at the screening sites with respiratory symptoms, i.e. cough or difficulty breathing AND
•One of the following: Increased respiratory rate for age OR indrawing OR SaO2 \< 93% OR grunting OR MUAC \< 11.5 if child is greater or equal than 6 months of age OR visible wasting AND
•Referred to clinician review for probable admission
•Definition of increased respiratory rate (rr) for age based on the WHO criteria: respiratory rate (rr) \> \> 50 for 2-11 month old; rr \> 40 for 1-5 years old.
•No symptoms or signs of any disease
•No malaria infection as detected by microscopy or RDT
•No history of clinical pneumonia or hospital admission

•An individual who meets any of the following criteria will be excluded from participation in this study:
•Suspected tuberculosis based on history of cough lasting \> 2 weeks
•Hospital admission in the previous 2 weeks.
•Children that show any evidence of other conditions that could be worsened by blood collection will be further excluded from this study.
•Having received a vaccine within the prior 4 weeks

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