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Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm | Clinical Trials | Clareo Health

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Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm

Efficacy and Safety of a New Chewable Tablet of Mebendazole Versus the Swallowable, Standard Tablet of Mebendazole Against Hookworm Infections in Children: a Randomized Controlled Trial

NCT03995680•Swiss Tropical & Public Health Institute

View on ClinicalTrials.gov

Summary

The rational of this study is to provide evidence on the safety and efficacy of a new chewable tablet of mebendazole compared to the standard tablet in preschool- and school-aged children infected with hookworm.

Eligibility

Age

3 - 12 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Male or female children aged between 3 and 12 years;
•Written informed consent signed by caregiver;
•Was examined by a study physician before treatment;
•Provided two stool samples at baseline;
•Hookworm EPG \> 100 and at least two Kato-Katz thick smears slides with more than one hookworm egg;

Exclusion Criteria

•Pregnant;
•Presence or history of major systemic or chronic illnesses, as assessed by a medical doctor, such as can upon initial clinical assessment;
•Suffers from severe anemia (Hb \< 80 g/l);
•Received anthelminthic treatment or metronidazole within past four weeks.
•Attending other clinical trials during the study.

Locations (1)

Public Health Laboratory Ivo de Carneri

Chake Chake, Tanzania

Key Dates

Start Date

July 12, 2019

Primary Completion Date

October 9, 2019

Completion Date

October 9, 2019

Last Updated

July 20, 2020

Enrollment

397

ACTUAL participants

Conditions

Hookworm Infections

Interventions

Mebendazole

DRUG

Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm

NCT05538767

Hookworm Infections

View study

UNKNOWNNA

Soil-transmitted Helminth Reinfection Rates After Single and Repeated School Hygiene Education

NCT04227834

HelminthiasisAscaris Infection+3 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 20, 2020Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm

Inclusion Criteria

Exclusion Criteria

Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm

Soil-transmitted Helminth Reinfection Rates After Single and Repeated School Hygiene Education

Mebendazole Study Against Hookworm Infections in Children and Adolescents in Ghana