SGLT2 Inhibitor or Metformin as Standard Treatment of Early Stage Type 2 Diabetes

Exclusion Criteria

• •Known or suspected other form of diabetes than type 2
• •Ongoing or more than \>4 weeks in total of any previous treatment with: insulin, GLP-1 receptor agonists, SGLT2 inhibitors or combination of any diabetes medications
• •Medical need to start or intensify any specific GLD treatment, e.g. insulin due to marked hyperglycemia
• •HbA1c \>70 mmol/mol for patients on monotherapy, \>80 in drug naïve
• •Contraindication to either metformin or dapagliflozin, or any unacceptable risk with either treatment as assessed by the investigator
• •History or signs of established cardiovascular disease: diagnosis of myocardial infarction, angina pectoris, heart failure, stroke, lower extremity arterial disease, any limb amputation (except due to trauma or malignancy)
• •Any serious illness or other condition with short life expectancy (\<4 yr)
• •Renal impairment (eGFR \<60 ml/min/1,73m2)
• •Any condition, as judged by the investigator, that suggests that the patient will be non-compliant or otherwise unsuitable to study medication or study participation
• •Pregnancy or breastfeeding, women of childbearing potential (WOCBP; including perimenopausal women who have had a menstrual period within 1 year) without adequate anticonception during any part of the study period
• •Involvement in the planning and/or conduct of the study
• •Ongoing participation in another clinical trial.