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Tau PET Longitudinal Substudy Associated With: A Double-Blind, Placebo-Controlled Parallel-Group Study in Preclinical PSEN1 E280A Mutation Carriers Randomized to Crenezumab or Placebo, and in Non-randomized, Placebo-treated Non-carriers From the Same Kindred, to Evaluate the Efficacy and Safety of Crenezumab in the Treatment of Autosomal-Dominant Alzheimer's Disease
This substudy will evaluate the effect of crenezumab on the longitudinal tau burden in a subgroup of preclinical Presenilin1 (PSEN1) E280A mutation carriers and non-carriers, who were enrolled in study NCT01998841 (GN28352). Participants will receive up to three intravenous (IV) injections of \[\^18F\] Genentech Tau Probe 1 (GTP1) and will undergo a tau positron emission tomography (PET) scan after each IV injection of \[18\^F\]GTP1. The purpose of this substudy is to increase the understanding of disease progression in the preclinical stage of familial Alzheimer's Disease (AD).
Age
30 - 60 years
Sex
ALL
Healthy Volunteers
No
Grupo Neurociencias de Antioquia
Medellín, Colombia
Start Date
June 10, 2019
Primary Completion Date
April 19, 2022
Completion Date
April 19, 2022
Last Updated
March 15, 2024
114
ACTUAL participants
Crenezumab
DRUG
Placebo
DRUG
[^18F]GTP1
OTHER
Lead Sponsor
Hoffmann-La Roche
Collaborators
NCT07178210
NCT04123314
Data Source & Attribution
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