Iron Status, Maternal Depressive Symptoms, and Mother-child Interactions

NCT03944733•Penn State University

Summary

This study aims to examine the relation between iron status and maternal-child interactions as well as maternal depressive symptoms in mothers from central Pennsylvania.

Detailed Description

Investigators aim to follow mothers and their infants from 6 weeks to 6 months in the postpartum to understand the relation between iron status and mother-child interactions and depressive symptoms. During this period, iron deficient anemic mothers will receive an intervention with iron with the scope of improving iron status, reducing their depressive symptoms, and in turn, increasing the quality of parenting behaviors during mother-child interactions. The control group will be iron sufficient mothers who will receive a placebo.

Eligibility

Age

18 - 40 years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•1. Pregnant women between 18 - 40 years.
•2. Mother expects to be the primary caregiver for the infant for study duration and will allow infant to be enrolled in the study..
•3. Mother has no history of gastrointestinal or hematological disorders and not taking medications that interfere with hematopoiesis or absorption.
•4. After birth, the mother and baby are healthy, delivery was of one infant only, infant gestational age ≥ 38 weeks, infant weight ≥ 2500 g (5.5 lbs), neither the mom nor the infant received a blood transfusion at or since delivery, and mom agrees to discontinue use of any iron containing medications.

Exclusion Criteria

•1. Maternal age ≤ 18 and \> 40 years
•2. Evidence of a history of gastrointestinal or hematological disorders and evidence of taking medications that interfere with hematopoiesis or absorption.
•3. Severely anemic (Hemoglobin \< 90 g/L)
•4. Iron deficient but not anemic women
•5. Non-English speaking

Key Dates

Start Date

December 1, 2019

Primary Completion Date

December 30, 2020

Completion Date

December 30, 2020

Last Updated

November 20, 2025

Conditions

Iron Deficiency Anemia

Interventions

Iron

DIETARY_SUPPLEMENT

Gelatin

DIETARY_SUPPLEMENT

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 20, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Iron Status, Maternal Depressive Symptoms, and Mother-child Interactions

Inclusion Criteria

Exclusion Criteria

Impact of Benazir Nashonuma Program (BNP) on Maternal and Child Nutritional Status

Nutritional Educational Program On Therapy in Iron Deficiency Anemia

Daily Versus Alternate Day Regimen of Iron Supplementation in Children with Iron Deficiency Anemia

Assessing Clinical Impact of AI for Iron Deficiency

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