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Locomotor Function Following Acute Intermittent Hypoxia (AIH) and Transcutaneous Electrical Spinal Cord Stimulation (tSCS) With Gait Therapy Versus Traditional Gait Therapy in Individuals With Spinal Cord Injury
This is a single blind, sham controlled crossover trial that will evaluate the effectiveness of acute intermittent hypoxia therapy (AIH) combined with transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals after spinal cord injury.
OBJECTIVES: * To determine whether acute intermittent hypoxia therapy (AIH) combined with transcutaneous spinal cord stimulation during ambulation training modulates spinal locomotor networks in individuals with spinal cord injury * To determine whether acute intermittent hypoxia therapy (AIH) combined with transcutaneous spinal cord stimulation during ambulation training improves locomotor function in individuals with spinal cord injury * To determine whether acute intermittent hypoxia therapy (AIH) combined with transcutaneous spinal cord stimulation during ambulation training improves symmetry of gait in individuals with spinal cord injury * To determine whether acute intermittent hypoxia therapy (AIH) combined with transcutaneous spinal cord stimulation during ambulation training improves standing posture and balance in individuals with spinal cord injury * To determine whether ambulation efficiency (improved cardiovascular conditioning) improves with a combination of AIH, transcutaneous spinal cord stimulation and ambulation training in individuals with spinal cord injury
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Shirley Ryan AbilityLab
Chicago, Illinois, United States
Start Date
December 1, 2020
Primary Completion Date
January 3, 2023
Completion Date
January 3, 2023
Last Updated
January 13, 2026
14
ACTUAL participants
Acute Intermittent Hypoxia + Non Invasive Spinal Cord Stimulation + Gait Training
DEVICE
Sham Acute Intermittent Hypoxia + Non Invasive Spinal Cord Stimulation + Gait Training
OTHER
Sham Acute Intermittent Hypoxia + Sham Non Invasive Spinal Cord Stimulation + Gait Training
OTHER
Lead Sponsor
Shirley Ryan AbilityLab
Collaborators
NCT06521723
NCT05563103
NCT07386522
Data Source & Attribution
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