Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study

Exclusion Criteria

• •Motor incomplete spinal cord injury AIS D (i.e. at least half (half or more) of the key muscle functions below the neurological level of injury (NLI) have a muscle grade greater than or equal to 3/5)
• •Spinal cord injury with sensory deficit only (i.e. no motor deficit)
• •Penetrating spinal cord injury (including gunshot wounds)
• •Isolated radiculopathy
• •Isolated cauda equina injury or spinal injury below L1
• •Associated injury (soft tissue or bony) to the lumbar spine where the intrathecal catheter would be placed
• •Associated traumatic conditions that would interfere with the outcome assessment (e.g., traumatic brain injury, chest, pelvis, abdomen, or femur injury requiring operative intervention)
• •Pre-existing neurodegenerative disorder, such as Parkinson's disease, Alzheimer's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis
• •Pre-existing thromboembolic disease or coagulopathy, such as hemophilia, von Willebrand disease
• •Presence of systemic disease that might interfere with patient safety, compliance or evaluation of the condition under study (e.g., clinically significant cardiac disease, HIV, Hep B or C) HTLV-1
• •Pre-existing inflammatory or autoimmune disorder (e.g. rheumatoid arthritis, systemic lupus, psoriasis, or ankylosing spondylitis
• •Any other medical condition that in the investigator's opinion would render the protocol procedures dangerous or impair the ability of the patient to receive protocol therapy
• •Female patients who are pregnant