Loading clinical trials...

UNKNOWNPHASE1

The Effect of Topical Curcumin Versus Topical Corticosteroid on Management of Oral Lichen Planus Patients

The Effect of Topical Curcumin Versus Topical Corticosteroid on Pain, Clinical Parameters and Salivary Level of IL-33 in Oral Lichen Planus Patients: A Randomized Controlled Clinical Trial

NCT03877679•Cairo University

View on ClinicalTrials.gov

Summary

Introduce a new anti-inflammatory and antioxidant paste preparation (curcumin paste) in the management of Oral lichen planus. * Assess the efficacy of this preparation on pain, clinical parameter and the level of IL-33 in saliva. * Compare the outcome of new preparation with the gold standard treatment (corticosteroids).

Detailed Description

Two groups will be prepared then decision of which one take curcumin paste will be selected according to randomized numbers in a sequentially numbered, opaque, sealed envelope 1 group will take topical corticosteroid and 1 will take curcumin paste then IL-33 level in saliva will be measured at the base line and at the end of 4th week pain and clinical parameters will be measured at 2nd and 4th week

Eligibility

Age

All ages

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Patients who will be clinically diagnosed as having atrophic \&/or erosive oral lichen planus.
•Patients with controlled diabetes and/or controlled hypertension will be included in the study.
•Patients with no history of taking corticosteroids for the last 6 months
•Patients who agrees to take medication.

Exclusion Criteria

•Pregnant and lactating ladies.
•Patients with history of topical steroids during last 2 months \& systemic steroids during last 6 months.
•Patients with recent dental filling associated with the lesion or associated with recent drug administration.
•Patient with uncontrolled diabetes, uncontrolled hypertension, or those with positive HCV ab or HBs Ag.

Key Dates

Start Date

May 1, 2019

Primary Completion Date

May 1, 2020

Completion Date

June 1, 2020

Last Updated

March 18, 2019

Enrollment

ESTIMATED participants

Conditions

Oral Lichen Planus

Interventions

Triamcinolone

DRUG

Turmeric paste

DRUG

Evaluation of Efficacy and Safety of add-on Tofacitinib in Patients With Oral Lichen Planus

NCT07131813

Oral Lichen Planus

View study

RECRUITING

SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography

NCT06321003

Oral Squamous Cell CarcinomaOral Potentially Malignant Disorder+10 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 18, 2019Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

The Effect of Topical Curcumin Versus Topical Corticosteroid on Management of Oral Lichen Planus Patients

Inclusion Criteria

Exclusion Criteria

Evaluation of Efficacy and Safety of add-on Tofacitinib in Patients With Oral Lichen Planus

SYsteMatical Trained learnIng aLgorithms for Oral carcInogenesiS Interpretation by Optical Coherence Tomography

Thyme Honey for Management of Oral Lichen Planus

Dual-light Antibacterial Photodynamic Therapy as an Adjunctive Treatment to Corticosteroid Treatment in OLP

Evaluation of Artificial Intelligence in Diagnosis and Risk Assessment of Oral Potentially Malignant Disorders

Relationship Between Oral Lichen Planus and Autoimmune Thyroid Diseases