Pharmacological Activation of HMN for OSA Aim 2

Exclusion Criteria

• •Any medical condition other than well controlled hypertension and mild diabetes.
• •Any medication known to influence breathing, sleep/arousal, or muscle physiology.
• •Claustrophobia.
• •Inability to sleep supine.
• •Allergy to any of the medications tested in the protocol.
• •History of kidney stones, hypercalcemia, primary hyperparathyroidism, sarcoidosis, hypervitaminosis D.
• •Individuals with underlying cardiac disease, such as arrhythmias.
• •Individuals taking psychiatric medications, such as an MAO-I, SSRI or SNRI, or any of the studied medications for medical care.
• •For women: Pregnancy.
• •Pulmonary hypertension
• •Severe OSA with a mean SaO2 lower than 88%