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COMPLETEDEARLY_PHASE1

Pharmacokinetic Boosting of Osimertinib

Pharmacokinetic Boosting of Osimertinib in Patients With Non-small Cell Lung Cancer.

NCT03858491•Academisch Ziekenhuis Maastricht

Summary

The main objective of this study is to evaluate if systemic exposure of osimertinib (i.e. AUC) is increased when osimertinib is co-administered with cobicistat in patients with relatively low plasma trough concentration while receiving the standard osimertinib dose.

Detailed Description

Osimertinib is a new targeted agent registered for the treatment of patients with EGFR-mutated NSCLC. However, the costs of those new treatments are extremely high. Osimertinib is mainly metabolized by CYP3A4, and partially by CYP3A5. Combination of osimertinib with a strong CYP3A4-inhibitor may result in a smaller first-pass effect and a decreased clearance of osimertinib, thereby increasing the exposure to osimertinib. Cobicistat is a strong CYP3A4-inhibitor, this mechanism may be used to boost osimertinib, as is done for other drugs, mainly drugs used to treat HIV-infected patients. Using this personalized treatment approach and combining the concepts of therapeutic drug monitoring (TDM) and pharmacokinetic boosting, osimertinib therapy could become much more cost-effective. By reducing the necessary dose of osimertinib, this strategy may ultimately result in a significant reduction in drug costs, as the additional expenditure for the CYP3A4 inhibitor and blood sample analysis are negligible compared to the price of osimertinib.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients with EGFR-mutated NSCLC receiving standard treatment with osimertinib for at least 2 months (steady state), without any signs of disease progression, or during treatment beyond progression, if treatment continuation is expected for multiple months. After anticipated EMA approval of osimertinib adjuvant therapy, patients on adjuvant osimertinib treatment may also participate on the following conditions; If they are receiving standard treatment with osimertinib for at least 2 months (steady state), and if treatment will be continued for a longer period than necessary for participation in the OSIBOOST trial.
•Age ≥ 18 years
•WHO performance status ≤ 2.
•Able and willing to give written informed consent.
•Able and willing to undergo blood sampling for pharmacokinetic analysis.
•Patients with osimertinib plasma trough concentration below 195 ng/mL. Plasma trough concentration of osimertinib will be determined in another study (METC MUMC: 2018-0800).

Exclusion Criteria

•Any concurrent medication that is known to strongly inhibit or induce CYP3A4.
•Any concurrent medication that is primarily metabolized by CYP3A4 with a narrow therapeutic window.
•Impairment of gastrointestinal function that may alter the absorption of osimertinib or cobicistat (e.g. ulcerative disease, uncontrolled nausea or vomiting, malabsorption syndrome, small bowel resection).
•Refusing to refrain from consuming CYP3A4 influencing products, e.g. grapefruit(juice), St. John's wort.
•Pregnancy or breast feeding
•Child-Pugh score class C, chronic liver disease.

Locations (2)

Maastricht University Medical Centre

Maastricht, Limburg, Netherlands

Antoni van Leeuwenhoek hospital

Amsterdam, North Holland, Netherlands

Key Dates

Start Date

November 1, 2020

Primary Completion Date

October 31, 2021

Completion Date

December 31, 2021

Last Updated

September 26, 2022

Enrollment

ACTUAL participants

Conditions

Non Small Cell Lung Cancer

Interventions

Cobicistat

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 26, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Pharmacokinetic Boosting of Osimertinib

Inclusion Criteria

Exclusion Criteria

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