COMPLETED

Safety and Efficacy of Lorbrena

Special Investigation for LORBRENA Tablets

NCT03844464•Pfizer

Summary

To investigate the following matters under post-marketing use of Lorbrena in patients who received this drug 1. Factors affecting the onset of central nervous system disorder 2. Effect of Lorbrena in combination with CYP3A inducers on the onset of hepatic dysfunction

Eligibility

Age

0 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•All administered patients

Exclusion Criteria

•Nothing

Locations (1)

3-22-7, Yoyogi, Shibuya-ku

Tokyo, Japan

Key Dates

Start Date

January 21, 2019

Primary Completion Date

July 30, 2025

Completion Date

July 30, 2025

Last Updated

September 4, 2025

Enrollment

1,290

ACTUAL participants

Conditions

Non-small Cell Lung Cancer

Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)

NCT06305754

Non-small Cell Lung Cancer (NSCLC)

View study

RECRUITINGPHASE3

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

NCT07190248

Non-small Cell Lung Cancer

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 4, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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RECRUITING

PHASE2/PHASE3