Epigenetic Regulation in Fibrous Dysplasia of Bone: mirDYS Study.

Exclusion Criteria

• •Refusal to participate in the study
• •Long- term corticosteroids treatment (\> 3 months)
• •Treated osteoporosis
• •Chronic inflammatory rheumatism (rheumatoid arthritis, psoriasic arthritis, spondyloarthropathy)
• •Collagen disease (osteogenesis imperfecta…)
• •Paget's disease, benign bone tumors
• •Uncontrolled hypo/hyper-thyroidism, hypo/hyper-parathryoidism
• •Severe renal impairment (GFR \< 30 ml/min/1.73m2)
• •Cancer or bone metastases (current or in the past two years)
• •Paget disease, benign bone tumor (osteoid osteoma, enchondroma …)
• •Malabsorptive disease (Celiac disease, Whipple's disease, intestinal bypass, short bowel syndrome) and inflammatory bowel disease
• •Pregnant women or lactating
• •Psychiatric disorders
• •Difficulty in understanding French
• •Not a beneficiary of french social security
• •Patients protected by law