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To understand the effects induced by acute hypoxia that sets in during surgery in breast cancer. To study this, clinical samples (Tumor biopsies) will be obtained during the surgery after partial devascularisation (sample B) and stored for future genomic and proteonomic evaluations.
Three tumor samples will be obtained after the patient is under anaesthesia, 1. Prior to starting surgery (Sample A) 2. The middle intra-operative sample, which will be collected when half the tumour has been devascularized (i.e., somewhere midway during the surgery). (Sample B) 3. A third post excision (anoxic sample C). These tumour tissue samples will be stored as snap frozen, in RNA later and as paraffin sections. To understand the effects induced by acute hypoxia that sets in during surgery in breast cancer. To study this, clinical samples (Tumor biopsies) will be obtained during and stored for future genomic and proteonomic evaluations.
Age
18 - No limit years
Sex
FEMALE
Healthy Volunteers
No
Tata Memorial Center
Mumbai, Maharashtra, India
Start Date
November 27, 2017
Primary Completion Date
September 30, 2025
Completion Date
November 30, 2025
Last Updated
September 10, 2025
500
ESTIMATED participants
Intra-operative Tumor Tissue Biopsy
PROCEDURE
Lead Sponsor
Tata Memorial Hospital
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT05116449