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Pharmacokinetics of Antiepileptic Drugs in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy
The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to characterize drug pharmacokinetics and optimize dosing strategies in patients on CRRT.
Age
18 - 80 years
Sex
ALL
Healthy Volunteers
No
University of Maryland Medical Center
Baltimore, Maryland, United States
Start Date
November 20, 2017
Primary Completion Date
December 31, 2019
Completion Date
December 31, 2019
Last Updated
October 5, 2021
18
ACTUAL participants
Levetiracetam
DRUG
Lacosamide
DRUG
Phenytoin
DRUG
Phenobarbital
DRUG
Ketamine
DRUG
Valproic Acid
DRUG
Lead Sponsor
University of Maryland, Baltimore
NCT05806645
NCT07472426
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT07447791