Oral Arsenic Trioxide for Newly Diagnosed Acute Promyelocytic Leukaemia

Exclusion Criteria

• •ECOG performance status above 2
• •Decompensated heart failure with left-ventricular ejection fraction of less than 40% and global hypokinesia on echocardiogram.
• •Prolonged corrected QT interval (QTc) \> 500ms, in the absence of electrolyte disturbances and medications known to prolong QTc
• •Significant liver function derangement (Bilirubin \> 3 times upper limit normal and/or ALT \> 5 times upper limit of normal)
• •Acute myeloid leukaemia with variant RARA translocation