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Keep this study
Lead
Washington University School of Medicine
With
National Institutes of Health (NIH)
University of Missouri, St. Louis
Temple University
University of California, San Diego
This proposal systematically characterizes brain efficiency and recruitment in virologically suppressed persons living with HIV (PLWH) and demographically similar HIV uninfected (HIV-) controls. This proposal collects advanced functional neuroimaging that provide critical information about cerebral blood flow (CBF) and brain connectivity (functional connectivity strength; FCS); quantitative measures of immune dysfunction in the blood and cerebrospinal fluid (CSF) (immune activation and immune exhaustion); and neuropsychological performance testing. This overall goal of this proposal is to delineate the interplay between dysfunction in frontal networks and recruitment of compensatory networks that underlie the neuropsychiatric symptoms seen in PLWH.
Age
20–80
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
20 to 80 years old
documented HIV infection for at least 1 year or confirmed HIV - status
PLWH must be on stable cART regimen for at least 12 months with undetectable plasma HIV RNA (less than 50 copies per mL)
at least 9 years of education
able to provide informed consent
if female, a negative pregnancy test and not breast feeding
able to undergo an MRI scan
You may not be if
significant neurological disorders (e.g. stroke, head injury with loss of consciousness for more than 5 minutes, developmental learning disability)
active uncontrolled Axis I psychiatric disorder according to the DSM 5
current or history of substance use disorder (including, but not limited to amphetamines, cocaine, alcohol, opiates, and barbiturates)
prescribed blood thinners
allergic to lidocaine or similar anesthetic
history of any bleeding disorder
contraindication to MRI scanning (e.g. claustrophobia, pacemaker, etc.)
pregnant or breastfeeding
Clareo Health | Functional Imaging Reserve in NeuroHIV
