5-HTP in Patients With IBD in Clinical and Biologic Remission:Effect on Fatigue Scores

Exclusion Criteria

• •The subject has a clinical validated depression
• •The subject is taking antidepressives or neuroleptics
• •The subject has a psychiatric comorbidity
• •The subject has important comorbidities: cardiovascular disease, obstructive lung pathology, neoplasia or other
• •The subject has a documented Anemia (based on lab results including Hb \< 12-13 g/dl respectively for saturation index \< 20%, Vit B12 \< 148 pmol/L or folic acid \< 6 nmol/L)
• •The subject has a documented hypothyreoidea (documented by a recent lab result including TSH)
• •The subject reports an infection within 2 weeks before inclusion
• •The subject reports any change in IBD medication (biologicals and immunosuppressives) in the last 12 weeks before inclusion
• •The subject was treated with oral corticosteroids during the last 8 weeks before enrolment
• •The subject reports an ongoing pregnancy or breastfeeding
• •The subject has a history of lymphoproliferative disease or cancer other than basocellular skin cancer
• •The subject underwent surgery in the past 12 weeks prior to the screening visit
• •The subject reports a history of clinically significant drug abuse (defined as any illicit drug use) or alcohol abuse within 1 year prior to inclusion