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Retrospective Analysis of Clinical Factors Associated With Greater Benefit of Axitinib in Metastatic Renal Cancer (AXILONG Study)
Retrospective study to collect data from Patients with advanced/metastatic renal cell carcinoma previously treated with Axitinib under standard clinical practice, to describe the clinical profile of the patients with a long response to Axitinib and to try to identify clinical factors which could be related with the long response to Axitinib, through the comparison between long responder patients and a group of refractory patients
To describe the clinical profile of patients with a long response to Axitinib and to identify clinical factors which could be related with the long response to Axitinib, through the comparison between long responder patients and a group of refractory patients. For this study are defined as "long responder", those patients who has a Progression Free Survival (PFS) of at least 9 months since the initiation of Axitinib treatment, and "refractory patients" those who have Progression Disease (PD) in the first response assessment since the initiation of Axitinib treatment (estimated PFS ≤3 months\] Secondary Objectives * To describe the efficacy of Axitinib treatment in the long responders group, and in relation with the treatment received before Axitinib, in terms of PFS, ORR, CB, OS, TTP ... * To describe the tolerability and drug management of Axitinib in this population. * To describe treatment received after Axitinib in this population. Study procedures: For the recruitment, the Investigator should review the inclusion / exclusion criteria. In case of patients alive at the moment of the inclusion, the investigator will require them to sign the IC. With the data available in the medical records, the information requested will be recorded in the electronic data collection tool.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Hospital Duran i Reynals
L'Hospitalet de Llobregat, Barcelona, Spain
Hospital Universitario Parc Taulí
Sabadell, Barcelona, Spain
Hospital Sant Pau i Santa Tecla
Tarragona, Barcelona, Spain
Hospital Universitario Mutua Terrassa
Terrassa, Barcelona, Spain
Complejo Hospitalario la Mancha Centro
Alcázar de San Juan, Ciudad REAL, Spain
Hospital Universitario Principe de Asturias
Alcalá de Henares, Madrid, Spain
Hospital Universitario Fundacion Alcorcón
Alcorcón, Madrid, Spain
Hospital Universitario Severo Ochoa
Leganés, Madrid, Spain
Hospital Universitario Rey Juan carlos
Móstoles, Madrid, Spain
Hospital Infanta Cristina
Parla, Madrid, Spain
Start Date
April 19, 2018
Primary Completion Date
March 1, 2019
Completion Date
March 1, 2019
Last Updated
February 17, 2022
157
ACTUAL participants
Lead Sponsor
Pfizer
NCT07227415
NCT05127824
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT05865730